Synthesis of novel thiazolylpyrazoline derivatives and evaluation of their antimicrobial activities and cytotoxicities

Authors : Aouatef TABBI, Zafer Asim KAPLANCIKLI, Dahmane TEBBANI, Leyla YURTTAŞ, Zerrin CANTÜRK, Özlem ATLI, Merve BAYSAL, Gülhan Turan ZITOUNI

Pages : 641-654

View : 22 | Download : 9

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :Several novel thiazolylpyrazoline derivatives were synthesized by reacting substituted 3,5-diaryl-1-thiocarba\-moyl-2-pyrazolines with phenacylbromides. The structures of the synthesized compounds were confirmed by IR, $^{1}$H NMR, $^{13}$C NMR, and MS spectral data. Their antimicrobial activities against Staphylococcus aureusinsert ignore into journalissuearticles values(ATCC-25923);, Enterococcus faecalis} insert ignore into journalissuearticles values(ATCC-29212);, Enterococcus faecalis insert ignore into journalissuearticles values(ATCC-51922);, Listeria monocytogenes insert ignore into journalissuearticles values(ATCC-1911);, Klebsiella pneumoniae insert ignore into journalissuearticles values(ATCC-700603);, Pseudomonas aeruginosa insert ignore into journalissuearticles values(ATCC-27853);, Escherichia coli insert ignore into journalissuearticles values(ATCC-35218);, Escherichia coli insert ignore into journalissuearticles values(ATCC-25922);, Candida albicans insert ignore into journalissuearticles values(ATCC-90028);, Candida glabrata insert ignore into journalissuearticles values(ATCC-90030);, Candida krusei insert ignore into journalissuearticles values(ATCC-6258);, and Candida parapsilosis insert ignore into journalissuearticles values(ATCC-22019); were investigated. The compounds were also studied for their cytotoxic effects using a MTT assay. Compound 7c showed the highest antimicrobial activity, possessing the same potential as chloramphenicol against K. pneumonia, P. aeruginosa, and E. coli insert ignore into journalissuearticles values(ATCC-25923);.
Keywords : 2 Pyrazoline, thiazole, thiazolylpyrazoline, antimicrobial activity, cytotoxicity