Isoquinoline-substituted triazole and pyran derivatives: synthesis and computational studies

Authors : Duygu YENİDEDE, Selçuk GÜMÜŞ, Ayşegül GÜMÜŞ

Pages : 655-666

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Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :The one-pot synthesis of novel 1,4-disubstituted 1,2,3-triazoles from isoquinoline-substituted homopropargyl alcohol backbone is described insert ignore into journalissuearticles values(42%-88% yields);. A ring closing metathesis reaction and an intramolecular Pauson-Khand reaction of enyne system derived from a homopropargyl alcohol backbone to afford the corresponding isoquinoline-substituted dihydropyran and cyclopentenone-pyran, respectively, are also described insert ignore into journalissuearticles values(54% and 78% yields);. Information about the structural, electronic, and physico-chemical properties of the novel compounds, obtained by density functional theory application, is also reported.
Keywords : Isoquinoline, 1, 2, 3 triazoles, ring closing metathesis reaction, Pauson Khand reaction