Recent advances in thymidine phosphorylase inhibitors: syntheses and prospective medicinal applications

Authors : MUHAMMAD AAMIR SAJID, Zulfiqar Ali KHAN, Sohail Anjum SHAHZAD, Syed Ali Raza NAQVI, Muhammad USMAN, Ahsan IQBAL

Pages : 1-28

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Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :This review paper covers recent advances in the synthetic strategies for novel TPase inhibitors and their potential medicinal applications over the last few decades. A brief introduction covering the structural aspects of TPase inhibitors is also included to facilitate understanding of diverse approaches to monitor the design of new inhibitors. TPase is an essential enzyme and its inhibition is a potential target in the development of anticancer drugs.
Keywords : Thymidine phosphorylase, platelet derived endothelial cell growth factor PDECGF, angiogenesis, thymidine phosphorylase inhibitors, anticancer drugs, inhibitor design