Synthesis and anticancer and cytotoxic effects of novel 1,4-phenylene-bis-N-thiocarbamoylpyrazole and 1,4-phenylene-bis-pyrazolylthiazole derivatives

Authors : MELİHA BURCU GÜRDERE, ERDOĞAN KAMO, YAKUP BUDAK, AYŞE ŞAHİN YAĞLIOĞLU, MUSTAFA CEYLAN

Pages : 179-189

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Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :Thiazolylpyrazoline derivatives were recently reported as potent anticancer agents. In this study, novel 1,4-phenylene-bis-N-thiocarbamoylpyrazoles insert ignore into journalissuearticles values(3a-h and 1,4-phenylene-bis-pyrazolylthiazoles insert ignore into journalissuearticles values(5a-h were prepared and screened for their anticancer activities against C6 insert ignore into journalissuearticles values(rat brain tumor cells); and HeLa insert ignore into journalissuearticles values(human uterus carcinoma);. Anticancer activity studies were performed as a dose-dependent assay starting with eight concentrations. 5-Fluorouracil insert ignore into journalissuearticles values(5-FU); was used as a positive control. Compounds 3c, 3d, and 3h were examined and they revealed almost the same activities compared with 5-FU in terms of cell selectivity against C6 cells. Moreover, compounds 3a-h had lower cytotoxicity than 5-FU. The low cytotoxicity values of 3a-h as well as their high antiproliferative activity were encouraging, but further studies are required on the use of these molecules as anticancer drugs.
Keywords : Bis chalcone, bis N thiocarbamoylpyrazole, bis pyrazolylthiazole, HeLa, C6, anticancer activity, cytotoxicity