Synthesis of novel derivatives of chromenone bearing an $N$-carbamothioyl moiety as soybean 15-LOX inhibitors

Authors : ROBABEH KAVIANI, MINA SAEEDI, MOHAMMAD MAHDAVI, HAMIND NADRI, ALIREZA MORADI, ABBAS SHAFIEE, TAHMINEH AKBARZADEH

Pages : 335-344

View : 15 | Download : 8

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :Novel derivatives of chromenone bearing an $N$-carbamothioyl moiety were synthesized and evaluated for their soybean 15-LOX inhibitory activity. Synthesis of the target compounds was started from 7-hydroxy-2$H$-chromen-2-one. It was reacted with 1-fluoro-2insert ignore into journalissuearticles values(4);-nitrobenzene to obtain the corresponding nitrophenoxy-chromenone derivative. Reduction of the nitro group was achieved in the presence of Zn/NH$_{4}$Cl and reaction of the latter compound with in situ prepared benzoyl isothiocyanate led to the formation of the title compounds. All compounds were characterized and tested against soybean 15-LOX. Among them, 4-methyl-$N$-insert ignore into journalissuearticles values(insert ignore into journalissuearticles values(4-insert ignore into journalissuearticles values(insert ignore into journalissuearticles values(2-oxo-2$H$-chromen-7-yl);oxy);phenyl);carbamothioyl);benzamide insert ignore into journalissuearticles values(7l); showed the best activity as potent as the reference drug, quercetin.
Keywords : Chromenone, nitro compounds, N carbamothioyl, soybean 15 LOX