Bis(indoline-2,3-diones): versatile precursors for novel bis(spirooxindoles) incorporating 4$H$-chromene-3-carbonitrile and pyrano[2,3-$d$]pyrimidine-6-carbonitrile derivatives

Authors : Said Ahmed Soliman GHOZLAN, Muhammed Aly RAMADAN, Amr Mohmed ABDELMONIEM, Ahmed H M ELWAHY, İsmail Abdelshafy ABDELHAMID

Pages : 410-419

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Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :Multicomponent reaction of dimedone or 1,3-dimethylbarbituric acid and malononitrile with a series of bisinsert ignore into journalissuearticles values(indoline-2,3-diones); afforded the corresponding bisinsert ignore into journalissuearticles values(2-amino-7,7-dimethyl-2`,5-dioxo-5,6,7,8-tetrahydrospiro[chromene-4,3`-indoline]-3-carbonitrile); and bisinsert ignore into journalissuearticles values(7`-amino-1`,3`-dimethyl-2,2`,4`-trioxo-1`,2`,3`,4`-tetrahydrospiro[indoline-3,5`-pyrano [2,3-d]pyrimidine]-6`-carbonitrile); derivatives in good to excellent yield.
Keywords : Bis indoline 2, 3 diones, bis spirooxindole, 4 H chromene 3 carbonitrile, pyrano 2, 3 d pyrimidine 6 carbonitrile