Diastereoselective synthesis of novel 2,5-dioxopyrrolidine derivatives via biocatalytic domino reactions

Authors : Saadieh MOHAJER, Robabeh BAHARFAR

Pages : 502-513

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Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :A series of novel 2,5-dioxopyrrolidines were synthesized by the one-pot reaction of coumarin-3-carboxylic acids 1 with thiourea derivatives and alkyl isocyanides in the presence of Fe$_{3}$O$_{4}$ NPs @ lipase as heterogeneous reusable nanobiocatalysts with high yields.
Keywords : Diastereoselective synthesis, 2, 5 dioxopyrrolidine derivatives, biocatalytic reactions