Synthesis and cytotoxicity evaluation of [(2,4-dichlorophenoxy)methyl]-5-aryl-1,3,4-oxadiazole/4 H -1,2,4-triazole analogues

Authors : Mohamed Jawed AHSAN

Pages : 1334-1343

View : 19 | Download : 7

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :We report herein the synthesis, characterization, and cytotoxicity evaluations of some newer oxadiazole and triazole analogues insert ignore into journalissuearticles values( 5a-j );. The cytotoxicity of all the title compounds were evaluated as per the National Cancer Institute protocol in a one-dose assay insert ignore into journalissuearticles values(10 μ ` role=`presentation`> μ μ \mu M); on nine different panels of 59 cancer cell lines. 2- { ` role=`presentation`> { { \{ 5-[insert ignore into journalissuearticles values(2,4-Dichlorophenoxy);methyl]-1,3,4-oxadiazol-2-yl } ` role=`presentation`> } } \} phenol insert ignore into journalissuearticles values( 5e ); showed the maximum cytotoxicity among the series of ten compounds. The cytotoxicity of 5e was comparable to that of the standard anticancer drug, 5-fluorouracil, and better than that of imatinib. The structure activity relationship was also discussed.
Keywords : Anticancer activity, cancer cell lines, cytotoxicity, one dose assay, oxadiazole, triazole