Synthesis of 2-substituted 8-propargyloxyquinoline derivatives and determination of their antioxidant, antibacterial, and DNA binding activities

Authors : Ayşegül GÜMÜŞ, Veysi OKUMUŞ, Selçuk GÜMÜŞ

Pages : 1358-1369

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Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :  2-Substituted 8-propargyloxyquinoline derivatives have been synthesized from 2-substituted-8-hydroxyquinolines by O-propargylation method insert ignore into journalissuearticles values(30%-98% yields);. The newly synthesized compounds were tested for in vitro antioxidant activities such as DPPH radical scavenging, ferrous chelating, and reducing power activities. The maximum radical scavenging insert ignore into journalissuearticles values(46.5%); and reducing power activities were obtained from 1 and maximum ferrous chelating effect was obtained from 6 insert ignore into journalissuearticles values(72.1%); at the concentration of 500 μ μ g/mL. To indicate DNA binding activity of the complexes calf thymus DNA was used. The compounds were also evaluated for their antimicrobial activity against three gram-positive and three gram-negative bacteria. Compounds 3 and 5 exhibited antibacterial activity against all tested gram-positive bacteria.
Keywords : Quinoline, propargyloxyquinoline, antioxidant, antibacterial, DNA binding activity