Facile synthesis of heteroaryl substituted -lactams from nitrovinyl arenes

Authors : Seda ÇINAR, Canan ÜNALEROĞLU

Pages : 29-35

View : 15 | Download : 9

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :Aliphatic nitroalkanes with different functional groups were synthesized from the Michael addition reactions of active methylene compounds 2 and nitrovinyl arenes 1 in high yields. The synthesized Michael adducts were subjected to intramolecular cyclization to give heteroaryl substituted γ-lactams in good to high yields under mild reaction conditions.
Keywords : γ Lactam, aliphatic nitroalkanes, Michael addition, nitrovinyl arenes