One-pot synthesis of new N-(1-methylpyridin-4(1H)-ylidene)amine ligands for palladium-catalyzed Heck coupling reaction

Authors : Muhammad ZAFAR, Sabeen ZAHRA, Muhammad TAHIR, Ehsan MUGHAL, Muhammad NAZAR, Hummera RAFIQUE

Pages : 63-74

View : 16 | Download : 9

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :A series of new derivatives of N-insert ignore into journalissuearticles values(1-methylpyridin-4insert ignore into journalissuearticles values(1H);-ylidene);amines, [L1]-[L5], were synthesized and characterized by FTIR, NMR, MS, and XRD analysis. These targeted compounds were synthesized by the melt reaction between N-methylated-4-chloropyridinium triflate and corresponding amines insert ignore into journalissuearticles values(1-naphthyl amine, o-ansidine, 2-nitroaniline, p-ansidine, and cyclohexyl amine); followed by the addition of sodium hydride in dichloromethane in the same pot. These highly electron-donating N-insert ignore into journalissuearticles values(1-methylpyridin-4insert ignore into journalissuearticles values(1H);-ylidene);amine ligands considerably improve the catalytic activity of palladium acetate towards Heck-Mizoroki carbon-carbon cross-coupling reactions.
Keywords : N 1 Methylpyridin 4 1H, ylidene, amines, pyridinium amido, Heck Mizoroki