Biological study on novel coumarinyl 1,3,4-oxadiazoles

Authors : Maja MOLNAR, Ana AMIC, Valentina PAVIC, Tihomir KOVAC, Marija KOVAC, Elizabeta HASSCHÖN

Pages : 146-157

View : 13 | Download : 8

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :Coumarinyl 1,3,4-oxadiazoles were synthesized from Schiff bases and acetic anhydride. All compounds were characterized by melting points and their structures conrmed by mass and $^{1}$H and $^{13}$C NMR spectrometry. These novel coumarinyl derivatives were subjected to antibacterial, antifungal, anta atoxigenic, and antioxidant activity. Their activity varied depending on their structure, where 2-insert ignore into journalissuearticles values(3-acetyl-5-insert ignore into journalissuearticles values(insert ignore into journalissuearticles values(insert ignore into journalissuearticles values(4-methyl-2-oxo-2H-chromen-7-yl);oxy);methyl);- 2,3-dihydro-1,3,4-oxadiazol-2-yl);-1,4-phenylene diacetate showed signicant antioxidant and antibacterial activity on B. subtilis. 4-insert ignore into journalissuearticles values(3-Acetyl-5-insert ignore into journalissuearticles values(insert ignore into journalissuearticles values(insert ignore into journalissuearticles values(4-methyl-2-oxo-2H-chromen-7-yl);oxy);methyl);-2,3-dihydro-1,3,4-oxadiazol-2-yl);-1,2-phenylene diacetate was found to possess excellent antifungal and antia atoxigenic activity.
Keywords : Coumarin, 1, 3, 4 oxadiazole, antibacterial, antifungal, antimycotoxigenic activity