Spectroscopic and thermodynamic approach to the interaction of nonperipherally substituted cationic phthalocyanines with calf thymus (CT)-DNA

Authors : Sevgican TUNCER, İbrahim ÖZÇEŞMECİ, Behice Şebnem SESALAN, Ayfer Kalkan BURAT

Pages : 274-290

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Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :Novel, nonperipherally tetrasubstituted cationic metal-free and metallophthalocyanines insert ignore into journalissuearticles values(Zn, In); were synthesized in the present study. The binding constants, the disappearance of quenching effect of all cationic phthalocyanines on the fluorescence intensity of SYBR Green--disodium salt of deoxyribonucleic acid insert ignore into journalissuearticles values(DNA); from calf thymus complex, and the changes in T$_{m}$ of double helix DNA with thermal denaturation profile were investigated by UV-Vis and fluorescence spectrophotometric methods. To investigate the spontaneity of the reactions between DNA and novel quaternized phthalocyanines in buffer, thermodynamic parameters were employed.
Keywords : Calf thymus CT, DNA, morpholine, quaternized phthalocyanines, Gibbs, entropy