Synthesis and biological properties of novel 1-methyl-2-(2-(prop-2-yn-1-yloxy)benzylidene) hydrazine analogues

Authors : Arif KIVRAK, Can YILMAZ, Metin KONUŞ, Halil KOCA, Selahattin AYDEMİR, Jeger Ali OAGAZ

Pages : 306-316

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Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :1-Methyl-2-insert ignore into journalissuearticles values(2-insert ignore into journalissuearticles values(prop-2-yn-1-yloxy);benzylidene);hydrazine analogues were readily prepared in good yields by the reaction of 2-insert ignore into journalissuearticles values(prop-2-yn-1-yloxy);benzaldehydes and methyl hydrazine. The reaction tolerates a variety of substituents on the 2-hydroxybenzaldehyde to form nitro-, halo-, methoxy-, and naphthyl-substituted 1-methyl-2-insert ignore into journalissuearticles values(2-insert ignore into journalissuearticles values(prop-2-yn-1-yloxy);benzylidene);hydrazines. The in vitro antioxidant capacity measurements revealed that among all the analyzed hydrazine analogues that surpassed the Trolox standard, 1-insert ignore into journalissuearticles values(2-insert ignore into journalissuearticles values(but-3-ynyl);-5-nitrobenzylidene);-2-methylhydrazine had the maximum value, which was approximately 1.7 times that of Trolox.
Keywords : Hydrazines, hydrazones, ABTS, antioxidant capacities, biological properties