Nickel(II)-PPh$_{3}$ complexes with ONS and ONN chelating thiosemicarbazones: synthesis and inhibition potential on influenza A viruses

Authors : Şükriye GÜVELİ, Kadir TURAN, Bahri ÜLKÜSEVEN

Pages : 371-384

View : 15 | Download : 8

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :Tetra-coordinated nickelinsert ignore into journalissuearticles values(II); complexes of two ONS insert ignore into journalissuearticles values(1, \2); and seven ONN insert ignore into journalissuearticles values(3a-3g); chelating 2-hydroxy-3-methoxy-benzaldehyde thiosemicarbazones were synthesized. The dibasic ligands and complexes bearing PPh$_{3}$ as a coligand were characterized by means of analytical and spectroscopic data. Cytotoxic activities of the ligands and nickelinsert ignore into journalissuearticles values(II); complexes were determined using the MTT assay in vitro against MDCK cells, and then all the compounds were tested on influenza virus replication by plaque assays. The compounds showed GI$_{50}$ values varying from concentrations of 15.9 up to 161.8 $\mu$ g/mL for MDCK cells. The plaque assays indicated that one ONS insert ignore into journalissuearticles values(1); and two ONN insert ignore into journalissuearticles values(3c and 3d); chelate structures have considerable antiviral effects on influenza A viruses at lower concentrations than the GI$_{50}$ values for MDCK cells. The ligands and other complexes did not show any inhibitory effects on influenza virus plaque formation. The effects of the compounds on the influenza virus and structure-antiviral activity relationships were discussed based on the donor atoms and S-alkyl substituents
Keywords : Thiosemicarbazone, Ni II, complexes, cytotoxic activity, antiviral, influenza A viruses