Synthesis, solvatochromism, and biological activity of novel azo dyes bearing 2-pyridone and benzimidazole moieties

Authors : Dusan MIJIN, Biljana Bozic NEDELJKOVIC, Bojan BOZIC, İlijana KOVRLIJA, Jelena LADAREVIC, Gordana USCUMLIC

Pages : 896-907

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Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :New azo dyes bearing 2-pyridone and benzimidazole moieties were prepared using diazotization of 4-insert ignore into journalissuearticles values(1H-benzo[d]imidazol-2-yl);aniline and coupling of the obtained diazonium salt with substituted 3-cyano-2-pyridones. Obtained compounds were characterized via UV-Vis, FT-IR, and $^{1}$H and $^{13}$C NMR spectroscopy as well as by elemental analysis data. The UV-Vis spectra of the synthesized dyes were measured in thirteen solvents of different properties at room temperature. Solvatochromism and tautomerism of novel azo dyes were discussed. An MTT insert ignore into journalissuearticles values(3,4,5-dimethyl-thiazol-2-yl);-2,5-diphenyl tetrazolium bromide); test was performed to prove the biocompatibility of the investigated dyes. The investigated dyes exhibited satisfying antiproliferative activities against both tumor cell lines, MDA-MB-231 and HCT-116, demonstrating the potent capacity for treatment of tumors.
Keywords : UV Vis spectroscopy, azo dyes, biocompatibility, antiproliferative activity, tautomerism