Voltammetric determination of glycopyrrolate in a pharmaceutical formulation

Authors : Muneer FADR, Abdulaziz Nabil AMRO, Sami Ben AOUN, Samer RATROUT, Fadi ASFOUR

Pages : 1736-1743

View : 15 | Download : 7

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :The electrochemical activity of glycopyrrolate was studied. Different voltammetric techniques were applied in this study, including cyclic voltammetry insert ignore into journalissuearticles values(CV);, differential pulse voltammetry insert ignore into journalissuearticles values(DPV);, and linear sweep voltammetry insert ignore into journalissuearticles values(LSV);. Glassy carbon and platinum working electrodes were utilized. CV indicated that glycopyrrolate has a reversible redox reaction on the working electrode surface, with an anodic peak current at approximately 1.05 V and a cathodic peak at 0.80 V. Several parameters that affect the sensitivity of these methods were optimized for the quantitation of glycopyrrolate. LSV showed a better correlation coefficient than DPV did, with a value of ca. 0.9990 in the range of 0.1-0.5 mg/mL. The LSV and DPV recovery and relative standard deviation insert ignore into journalissuearticles values(RSD); results fell within the accepted range, with a better recovery insert ignore into journalissuearticles values(102.07%); for DPV and a better RSD insert ignore into journalissuearticles values(0.511%); for LSV. The limits of detections were ca. 16 and ca. 25 μg/mL for LSV and DPV, respectively.
Keywords : Glycopyrrolate, linear sweep voltammetry, differential pulse voltammetry