1,2-Dibromotetrachloroethane: an efficient reagent for many transformations by modified Appel reaction

Authors : Selçuk EŞSİZ, Arif DAŞTAN

Pages : 150-156

View : 14 | Download : 5

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :An efficient and facile method has been developed for the synthesis of alkyl bromides from various alcohols under mild conditions using a triphenylphosphine insert ignore into journalissuearticles values(PPh$_{3});$/1,2-dibromotetrachloroethane insert ignore into journalissuearticles values(DBTCE); complex in excellent yields and very short time insert ignore into journalissuearticles values(5 min);. This method can also be applied for the transformation of chiral alcohols to their corresponding bromides in very high enantiomeric excess. The PPh$_{3}$/DBTCE complex is also successfully applied to ring-opening reactions of cyclic ethers in mild conditions. Esterification, amidation, and formation of acid anhydrides under very mild experimental conditions are also successfully accomplished by following a modification of the Appel reaction protocol in this work.
Keywords : Alkyl bromides, 1, 2 dibromotetrachloroethane, ring opening reaction, Appel reaction, configuration inversion