Efficient synthesis and antifungal investigation of nucleosides` quaternary ammonium salt derivatives

Authors : Barbara DMOCHOWSKA, Lucyna PELLOWSKAJANUSZEK, Justyna SAMASZKOFIERTEK, Rafal SLUSARZ, Roland WAKIEC, Janusz MADAJ

Pages : 157-171

View : 11 | Download : 5

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :Quaternary ammonium salts are a group of compounds with diverse biological properties, the most important of which are their antiviral, antibacterial, and antifungal activities. The quaternization reactions of 5`-$O$-tosyl derivatives of uridine and thymidine with triethylamine, trimethylamine, 4-insert ignore into journalissuearticles values($N$,$N$-dimethylamino);pyridine, 2-methylpyridine, and pyridine are described in this article. Two of the synthesized compounds are exceptional because they are first of this type that demonstrate concentration-dependent antifungal in vitro activity against two species of the genus Candida in minimal YNB-SG medium. The experimental results have been extended by adding full atom molecular dynamics simulations and substrates and products energies evaluation.
Keywords : Quaternary ammonium salts, uridine 5 extquotesingle ammonium derivatives, thymidine 5 extquotesingle ammonium derivatives