Chiral 1,4-aminoalkylphenols for enantioselective diethylzinc addition to aldehydes

Authors : Ömer DİLEK, Mustafa Ali TEZEREN, Tahir TİLKİ, Erkan ERTÜRK

Pages : 612-623

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Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :Starting from a chiral secondary alcohol, novel enantiopure 1,4-aminoalkylphenols insert ignore into journalissuearticles values(AAPs); were prepared by exploiting conventional organic transformations such as the Mitsunobu reaction, Eschweiler--Clarke N-methylation, and demethylation of anisoles. The catalytic activity of the 1,4-AAPs was investigated in enantioselective Et$_{2}$Zn addition to benzaldehyde. They were found to accelerate the Et$_{2}$Zn addition to benzaldehyde. High yields and enantioselectivities insert ignore into journalissuearticles values(e.g., 95% yield and 82% ee); were achieved.
Keywords : Asymmetric catalysis, aminoalcohols, aminoalkylphenols, diethylzinc addition