An exploration of new avenues regarding deep tissue penetration and higher singlet oxygen efficiencies: novel near-IR photosensitizers for photodynamic therapy

Authors : Nisa YEŞİLGÜL, Bilal KILIÇ

Pages : 624-633

View : 23 | Download : 8

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :A series of novel BODIPY-bearing electron-withdrawing groups at the meso position are reported here. According to the optical measurements, it may be clearly seen that the introduction of electron-donating groups into 3,5-positions and the presence of electron-withdrawing groups at the meso position of the BODIPY core resulted in spectacular bathochromic shifts insert ignore into journalissuearticles values(up to ∼ 304 nm);, and the projected photosensitizers had absorption bands in the therapeutic window of the electromagnetic spectrum insert ignore into journalissuearticles values(600-900 nm);. The absorption maxima of compounds 4,5,6, and 7 were at 886 nm, 890 nm, 760 nm, and 761 nm, respectively. The singlet oxygen generation experiments revealed that compounds 6 and 7, with high singlet oxygen quantum yields insert ignore into journalissuearticles values(0.52 and 0.93, respectively);, were excellent and promising candidates for photodynamic therapy. The singlet oxygen quantum yield of 0.93 was the highest reported value so far for BODIPY-based photosensitizers.
Keywords : BODIPY, photosensitizer, photodynamic therapy, singlet oxygen, near IR photosensitizer