Novel voltammetric investigation of dipyridamole at a disposable pencil graphite electrode

Authors : İulia Gabriela DAVID, Lorelei IORDACHE, Dana Elena POPA, Mihaela BULEANDRA, Victor DAVID, Emiliaelena IORGULESCU

Pages : 1109-1122

View : 13 | Download : 9

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :The present paper describes the voltammetric analysis of dipyridamole insert ignore into journalissuearticles values(DIP); at a cheap, disposable pencil graphite electrode insert ignore into journalissuearticles values(PGE);. The working conditions were optimized with regard to the electrode material and the supporting electrolyte. Cyclic voltammetric investigations emphasized that DIP is irreversibly oxidized at the PGE. The electrode process is pH-dependent and controlled by both diffusion and adsorption. For DIP quantitative determination a differential pulse voltammetric insert ignore into journalissuearticles values(DPV); method in phosphate buffer solution pH 7.00 was developed. DIP`s oxidation peak current varied linearly with the analyte concentration, presenting two linear ranges, namely 5.00 $\times $ 10$^{-7}$-2.50 $\times $ 10$^{-5}$ M and 2.50 $\times $ 10$^{-5}$-2.50 $\times $ 10$^{-4}$ M, with detection and quantification limits of 1.21 $\times $ 10$^{-7}$ M and 4.03 $\times $ 10$^{-7}$ M DIP, respectively. The newly developed DPV method using the inexpensive, disposable PGE was successfully applied for the simple and rapid determination of DIP from pharmaceutical formulations.
Keywords : Dipyridamole, voltammetry, disposable electrode, pencil graphite electrode, pharmaceuticals