Arene diazonium saccharin intermediates: a greener and cost-effective alternative method for the preparation of aryl iodide

Authors : Lıa ZAHARANI, Nader Ghaffarı KHALIGH, Zohreh SHAHNAVAZ, Mohd Rafıe JOHAN

Pages : 535-542

Doi:10.3906/kim-2002-26

View : 17 | Download : 12

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :In the current protocol, the arene diazonium saccharin derivatives were initially produced from various substituted aromatic amines; subsequently, these intermediates were treated with a greener organic iodide for the preparation of the aryl iodide. We tried to choose low-cost, commercially available, biodegradable, recoverable, ecofriendly, and safe reagents and solvents. The arene diazonium saccharin intermediates could be stored in the liquid phase into a refrigerator for a long time with no significant loss activity. The outstanding merits of the current protocol a included the partial recovering of saccharin and tetraethylammonium salt, b reduce the use of solvents and the reaction steps due to eliminating separation and purification of intermediates, c good yield of the sterically hindered substrates, and d avoid the generation of heavy metal or corrosive waste.
Keywords : Aromatic iodide, one pot diazotization iodination, saccharin, waste prevention