Cytotoxic and apoptotic potential of some coumarin and 2-amino-3-carbonitrile selenophene derivatives in prostate cancer

Authors : Metin YİLDİRİM, Mehmet ERSATİR, Badel ARSLAN, Elife Sultan GİRAY

Pages : 192-198

View : 13 | Download : 8

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :3-acetyl coumarin derivatives insert ignore into journalissuearticles values(1a-d); are formed as a result of condensation of salicylaldehyde derivatives and ethyl acetoacetate and were converted into coumarin-selenophene hybrid compounds insert ignore into journalissuearticles values(2a-d); in the basic medium by modified Gewald reaction in the presence of malononitrile and selenium. Products are characterized by nuclear magnetic resonance insert ignore into journalissuearticles values(NMR);. The prepared compounds are screened for their anticancer activity against DU-145 cell line. In addition, selected target compounds are evaluated for apoptosis and oxidative stress on DU-145 insert ignore into journalissuearticles values(prostate carcinoma); cell lines.
Keywords : Coumarin, selenophene, antitumor agents, antioxidant activity, heterocycles