Microwave assisted, sequential two-step, one-pot synthesis of novel imidazo[1,2-a] pyrimidine containing tri/tetrasubstituted imidazole derivatives

Authors : Tugba GUNGOR

Pages : 219-230

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Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :A series of novel imidazo[1,2-a]pyrimidine containing tri/tetrasubstituted imidazole derivatives insert ignore into journalissuearticles values(1-10); has been synthesized via sequential two-step, one-pot, multicomponent reaction using imidazo[1,2-a]pyrimidine-2-carbaldehyde, benzil, primary amines, and ammonium acetate catalyzed by p-toluenesulfonic acid under microwave-assisted conditions. The results showed that target compounds can be obtained from a wide range of primary amines bearing different functional groups with moderate to good yields insert ignore into journalissuearticles values(46%-80%); under optimum reaction conditions. This method provides a green protocol for imidazo[1,2-a]pyrimidine containing tri/tetrasubstituted imidazole derivatives due to ethyl alcohol as a green solvent, microwave irradiation as a greener heating method and one-pot multicomponent reaction as a green technique. The synthesized compounds have been elucidated using various spectroscopic tools such as FT-IR, H-1 NMR, C-13 NMR, and MS.
Keywords : Imidazo 1, 2 a pyrimidine, tri tetrasubstituted imidazole, microwave synthesis, sequential, one pot reaction, p toluenesulfonic acid