Design, synthesis, and spasmolytic activity of thiophene-based derivatives via Suzuki cross-coupling reaction of 5-bromothiophene-2-carboxylic acid: their structural and computational studies

Authors : Nasir RASOOL, Hafiz Mansoor IKRAM, Ammara RASHİD, Nazia AFZAL, Muhammad Ali HASHMİ, Muhammad Naeem KHAN, Ayesha KHAN, Imran IMRAN, Hafiz Muhammad Abdur RAHMAN, Syed Adnan Ali SHAH

Pages : 1410-1422

View : 27 | Download : 10

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :In the current research work, a facile synthesis of a series of novel thiophene-based derivatives of 5-bromothiophene-2-carboxylic acid insert ignore into journalissuearticles values(1); have been synthesized. All analogs insert ignore into journalissuearticles values(5a-5e, 10a-10t); were obtained from the coupling reaction of 5-bromothiophene2-carboxylic acid insert ignore into journalissuearticles values(1); and different arylboronic acids with moderate-to-good yields under controlled and optimal conditions. The structures of the newly synthesized compounds were characterized through spectral analysis and their spasmolytic activity, and most of the compounds exhibited potentially good spasmolytic effect. Among the synthesized analogs, compound phenethyl 5-insert ignore into journalissuearticles values(3,4-dichlorophenyl);thiophene-2-carboxylate insert ignore into journalissuearticles values(10d); particular showed an excellent spasmolytic effect with an EC50 value of 1.26. All of the compounds were also studied for their structural and electronic properties by density functional theory insert ignore into journalissuearticles values(DFT); calculations. Through detailed insight into frontier molecular orbitals of the compounds and their different reactivity descriptors, it was found that the compounds 10c and 5c are the most reactive, while 10a is the most stable in the series. Furthermore, compounds 10c and 5c showed a very good NW response with the highest beta values.
Keywords : Suzuki cross coupling reaction, 5 bromothiophene 2 carboxylic acid, density functional theory, spasmolytic activity