Mathematical modeling of a continuous-flow packed-bed reactor with immobilized lipase for kinetic resolution of (R,S)-2-pentanol

Authors : Asli SOYER MALYEMEZ, Abdulwahab GİWA, Emine BAYRAKTAR, Ulku MEHMETOGLU

Pages : 1423-1429

View : 17 | Download : 9

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :In this study, the kinetic resolution of insert ignore into journalissuearticles values(R,S);-2-pentanol via transesterification to achieve S-2-pentanol, a key intermediate required in the synthesis of anti-Alzheimer drugs, was investigated in continuous-flow packed-bed reactors. The effects of residence time, substrate concentration, and operation tune of the enzyme were investigated. Under steady state conditions, 50% conversion and enantiomeric excess of the substrate insert ignore into journalissuearticles values(eeinsert ignore into journalissuearticles values(s););>99% were achieved at a residence time of 0.04 min. Productivity of the continuous-flow process insert ignore into journalissuearticles values(1.341 mmol/min/g);was about 4 tunes higher than that of the corresponding batch process insert ignore into journalissuearticles values(0.363 mmol/min/g);. In addition, the mathematical modeling of the packed-bed reactor was conductedusing an axial dispersion model. Ping Pong Bi Bi kinetics was used in this model. Design parameters were determined and the developed equations were solved using an algorithm for solving boundary value problems for ordinary differential equations by collocation insert ignore into journalissuearticles values(bvp4c); using MATLAB. The results, obtained from the model, fitted the experimental data very well.
Keywords : R, S, 2 pentanol, anti Alzheimer drug intermediate, mathematical modeling of a packed bed reactor, axial dispersion, kinetic resolution