Voltammetric determination of itopride using carbon paste electrode modified with Gd doped TiO2 nanotubes

Authors : Abdulaziz Nabil AMRO, Khadijah EMRAN, Hessah ALANAZİ

Pages : 1122-1133

View : 23 | Download : 9

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :In the present work TiO2 nanotubes insert ignore into journalissuearticles values(TNT); have been synthesized by alkaline hydrothermal transformation. Then they have been doped with Gd element. Characterizations of doped and undoped TNT have been done with TEM and SEM. The chemical composition was analyzed by EDX, Raman and FTIR spectroscopy. The crystal structure was characterized by XRD. Carbon paste electrode has been fabricated and mixed with Gd doped and undoped TNT to form a nanocomposite working electrode. Comparison of bare carbon paste electrode and Gd doped and undoped TNT carbon paste electrode for 1.0 x10insert ignore into journalissuearticles values(-3); M K-4 [Feinsert ignore into journalissuearticles values(CN);insert ignore into journalissuearticles values(6);] voltammetric analysis; it was observed that Gd doped TNT modified electrode has advantage of high sensitivity. Gd doped TNT modified electrode has been used as working electrode for itopride assay in a pharmaceutical formulation. Cyclic voltammetry analysis showed high correlation coefficient of 0.9973 for itopride insert ignore into journalissuearticles values(0.04-0.2 mg/mL); with a limit of detection insert ignore into journalissuearticles values(LOD); and limit of quantitation values insert ignore into journalissuearticles values(LOQ); of 2.9 and 23.0 mu g.mLinsert ignore into journalissuearticles values(-1); respectively.
Keywords : Gd TiO2 nanotube, hydrothermal, cyclic voltammetry, itopride, nanocomposite electrode