Synthesis, biological evaluation of antioxidant-antibacterial activities and computational studies of novel anthracene- and pyrene-based Schiff base derivatives

Authors : Aysegul GUMUS, Veysi OKUMUS, Selcuk GUMUS

Pages : 1200-1215

View : 26 | Download : 8

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :Schiff base derivatives with anthracene- and pyrene-based units, Al-A6 and P1-P6 were synthesized insert ignore into journalissuearticles values(89%-99% yields);. Schiff base derivatives were designed to possess an heterocyclic moiety on one side to enhance the coordination ability towards metals. To investigate the biological assay of the newly synthesized compounds, their DPPH insert ignore into journalissuearticles values(2,2-diphenyl-1-picrylhydrazyl); radical scavenging, metal chelating, reducing power, antibacterial and DNA binding activities were tested. A6 insert ignore into journalissuearticles values(63.1%); showed the maximum free radical scavenging activity among all. However, compound P3 at concentration of 200 mu g/mL possessed the highest metal chelating insert ignore into journalissuearticles values(45.8%); activity and power of reduction. In addition, P3 and A6 showed antibacterial activity against all bacteria tested and both compounds were very well bound to CT-DNA. Density functional theory method with B3LYP/6-311++ Ginsert ignore into journalissuearticles values(d,p); basis set was performed to get information about the structural and electronic properties of the present compounds. In addition, the metal coordination properties of the dimers of the parent Schiff bases were investigated through interactions with Zn2+.
Keywords : Anthracene, pyrene, Schiff base, antioxidant, antibacterial, electronic properties