Lipid peroxidation in neoplastic tissue of dogs with mammary cancer fed with different kinds of diet

Authors : Maria KARAYANNOPOULOU, Anna FYTIANOU, Nikolaos ASSALOUMIDIS

Pages : 449-453

Doi:10.3906/sag-1208-60

View : 23 | Download : 9

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :Increased lipid peroxidation due to reactive oxygen species insert ignore into journalissuearticles values(ROS);-induced oxidative stress has been demonstrated in the neoplastic mammary tissue of dogs with malignant mammary tumors. Dietary factors implicated in ROS production may influence mammary cancer incidence or prognosis. Balanced diets insert ignore into journalissuearticles values(as commercial dog food is considered); may be more protective against oxidative damage than homemade diets. The purpose of this preliminary study was to compare the extent of lipid peroxidation, as evidenced by thiobarbituric acid-reactive substances insert ignore into journalissuearticles values(TBARS); and a-tocopherol concentration in the neoplastic mammary tissue, among dogs with mammary cancer fed with different kinds of diet insert ignore into journalissuearticles values(commercial or homemade);. Eighteen dogs with mammary cancer, assigned into 2 groups according to diet, were used. Neoplastic and normal mammary tissue , 1 cm3 each, was used for TBARS and a-tocopherol measurements. Serum TBARS, a-tocopherol, total cholesterol, and triglycerides were also measured. No significant differences in serum parameters evaluated were found between the 2 diet groups. The increased lipid peroxidation due to oxidative stress induction insert ignore into journalissuearticles values(increased TBARS and decreased a-tocopherol concentration); found in neoplastic compared to normal mammary tissue of dogs with mammary cancer was similar in both groups of dogs fed with a different kind of diet, commercial or homemade.
Keywords : Key words a Tocopherol, antioxidants, dog, lipid peroxidation, mammary tumors, oxidative stress