Hemodynamic effects of fluid resuscitation with 6% hydroxyethyl starch and whole blood in experimental hypovolemic shock in Beagle dogs

Authors : Jae Jin KO, Md Rafiqul ALAM, Nam Soo KIM

Pages : 416-423

Doi:10.3906/sag-1204-20

View : 13 | Download : 10

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :The short-term effects of 6% hydroxyethyl starch insert ignore into journalissuearticles values(HES); and whole blood insert ignore into journalissuearticles values(WB); resuscitations in hypovolemic shock insert ignore into journalissuearticles values(HS); on invasive and noninvasive hemodynamic variables were studied from the clinical point of view in 20 mature healthy male Beagle dogs. After anesthesia, the animals were randomly divided into 2 groups, HES insert ignore into journalissuearticles values(n = 10); and WB insert ignore into journalissuearticles values(n = 10);, and were surgically instrumented with an arterial catheter and a thermodilution cardiac output catheter. For induction of HS, the right carotid artery was catheterized and approximately 40% of the blood volume was drawn over a period of 30 min, until a mean arterial blood pressure insert ignore into journalissuearticles values(MAP); of about 50 mmHg was reached. After that, the HES group received 6% HES and the WB group received autologous whole blood resuscitation insert ignore into journalissuearticles values(30 mL/kg/h);. The measurement of hemodynamic variables was performed in normovolemic insert ignore into journalissuearticles values(baseline, BL);, severe hypovolemic, and resuscitation state insert ignore into journalissuearticles values(from R1 to R4 at an interval of 30 min);. Significant changes in some of the hemodynamic variables systolic arterial pressure insert ignore into journalissuearticles values(SAP);, diastolic arterial pressure insert ignore into journalissuearticles values(DAP);, MAP, central venous pressure insert ignore into journalissuearticles values(CVP);, cardiac output insert ignore into journalissuearticles values(CO);, cardiac index insert ignore into journalissuearticles values(CI);, stroke volume insert ignore into journalissuearticles values(SV);, stroke volume index insert ignore into journalissuearticles values(SVI);, oxygen delivery insert ignore into journalissuearticles values(DO2);, and oxygen consumption insert ignore into journalissuearticles values(VO2); were observed during hypovolemic shock and resuscitation, which could reflect the condition of the patient. Resuscitation with WB seemed to resolve the hemodynamic variables to or above BL, whereas that with HES could resolve most but not all of the hemodynamic variables. The WB was found to be superior to restore the hemodynamic variable to the BL or above in comparison to that of the HES, for the clinical management of HS in dogs. The findings of this study suggest that dogs in HS can be successfully resuscitated with HES and WB.
Keywords : Key words Hypovolemic shock, hemodynamic variables, resuscitation, whole blood, hydroxyethyl starch, Beagle dogs