Optimum timing for operation in bitches with pyometra related to endotoxemia

Authors : Melih UÇMAK, Çağatay TEK, Mehmet C GÜNDÜZ, Ahmet SABUNCU, Adem ŞENÜNVER

Pages : 35-42

View : 13 | Download : 7

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :The aim of this study was to evaluate the plasma levels of endotoxin in bitches with pyometra and to investigate the effects of preoperative supportive therapy on plasma endotoxin levels insert ignore into journalissuearticles values(LPS);, the complete blood count, serum biochemistry parameters insert ignore into journalissuearticles values(alanine amino transferase insert ignore into journalissuearticles values(ALT);, alkaline phosphatase insert ignore into journalissuearticles values(ALP);, total protein, albumin, urea, and creatinine);, clinical health status at the 12th, 24th, and 48th h following presentation, and to explore if they were correlated. Randomly allocated into 2 equivalent groups were 20 bitches with pyometra, aged from 3 to 16 years insert ignore into journalissuearticles values(mean 9.15 ± 3.65 years);. After collection of the samples, bitches in ovariohysterectomy without premedical supportive therapy insert ignore into journalissuearticles values(group OH); were operated on without delay. Bitches in ovariohysterectomy with premedical supportive therapy insert ignore into journalissuearticles values(group M); were operated on with a 48 h delay. Bitches with pyometra receiving supportive therapy had no significant difference in endotoxin levels insert ignore into journalissuearticles values(P < 0.001);, total blood counts, or serum biochemical parameters, which were evaluated along with food intake and activity scores during the 2 day period. There was a moderate positive correlation between LPS insert ignore into journalissuearticles values(endotoxin); and WBC insert ignore into journalissuearticles values(white blood cell);, ALP insert ignore into journalissuearticles values(alkaline phosphatase);, and creatinine levels and a moderate negative correlation between LPS, activity, and food intake scores at the 12th h evaluation. In conclusion, against the probability of high levels of circulating endotoxins in pyometra cases, bitches must undergo surgery at an optimum time, which is thought to be within 12 h of supportive therapy.
Keywords : Key words Pyometra, bitches, endotoxin, supportive therapy