Malignant giant-cell tumor of bone with lymph node involvement in a cat

Authors : Ahmet AKKOÇ, Gürsel SÖNMEZ, Kemal YANIK, Aylin Alasonyalilar DEMİRER, Nihal Y GÜL

Pages : 369-373

View : 23 | Download : 8

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :The present study describes giant-cell tumor of bone insert ignore into journalissuearticles values(GCToB); with lymph node involvement in a 5-year-old crossbred cat. The animal was referred to the surgery clinic with progressive subcutaneous swelling in the left proximal femoral region, severe lameness, constipation, and dysuria. A moderately firm, subcutaneous, palpable mass, 9 cm in diameter, was observed, and biopsy samples were taken. Histopathologically, the mass was constituted by ovoid-shaped mononuclear cells intermixed with many multinucleated giant cells insert ignore into journalissuearticles values(MGC);. Immunohistochemically, the giant cells were positively stained with antivimentin, and the same cells were negative for antidesmin and anti-S100 staining. Tartrate-resistant acid phosphatase insert ignore into journalissuearticles values(TRAP); activity in tumor cells was evaluated and the tumor was diagnosed as malignant GCToB; the cat was euthanized. Macroscopically, while the regional lymph nodes were intact, giant cells were found in the left popliteal lymph node during microscopy. Although a few cases of GCToB have been reported in cats, the case herein displays, for the first time, evidence of lymph node involvement during the process of metastasis.
Keywords : Key words Cat, giant cell tumor of bone, femur, lymph node involvement, immunohistochemistry