The increase of CD4+CD25+ T cells in the peripheral blood of pigs persistently infected with porcine reproductive and respiratory syndrome virus

Authors : Jingwen ZENG, Danting HE, Xin GUO, Xinna GE, Hanchun YANG

Pages : 177-182

View : 17 | Download : 6

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :Regulatory T lymphocytes insert ignore into journalissuearticles values(T-regs); may be involved in suppressing the host`s immunity, which is important for viral clearance, and may therefore contribute to persistent viral infection. However, nothing is known regarding the situation of porcine T-regs during persistent infection with porcine reproductive and respiratory syndrome virus insert ignore into journalissuearticles values(PRRSV);. This study, which used flow cytometry and real-time PCR, determined that the frequencies of CD4+CD25+ T-cells and porcine Forkhead/winged helix transcription factor insert ignore into journalissuearticles values(FoxP3); mRNA levels in peripheral blood significantly increased during PRRSV persistence, indicating that CD4+CD25+ T-regs might play an important role in PRRSV persistent infection. This study contributes to a better understanding of the immunological basis of PRRSV persistence.
Keywords : Key words Porcine reproductive and respiratory syndrome virus, PRRSV, persistent infection, CD4 CD25 T regs, FoxP3