Single intramuscular administration of long-acting oxytetracycline in grouper (Epinephelus marginatus)

Authors : George RIGOS, Pantelis KATHARIOS, Nikos PAPANDROULAKIS

Pages : 441-445

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Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :The plasma concentration of long-acting oxytetracycline insert ignore into journalissuearticles values(OTC-LA); was measured following a single intramuscular insert ignore into journalissuearticles values(IM); injection insert ignore into journalissuearticles values(50 mg/kg); in grouper insert ignore into journalissuearticles values(Epinephelus marginatus);, a common inhabitant of marine aquaria and a potential candidate for fish farming. The experiment was carried out at 20 °C and sampling points were selected at 0.25, 0.5, 1, 2, 4, 6, 8, 12, 24, and 48 h post-administration. OTC concentration in grouper circulation was maintained at high levels for the whole experiment insert ignore into journalissuearticles values(8.35-39.67 mg/mL); with maximum plasma concentration measured at 1 h post-injection. The area under the curve values was also promising since AUC0-24 and AUC 0-48 were calculated to be high insert ignore into journalissuearticles values(363.45 and 668.73 mg h/mL, respectively);. Due to the high OTC levels accomplished for prolonged period of time, a single administration of OTC-LA could be an ideal route in cases when multiple handling is unwanted and big animals such as grouper are to be treated.
Keywords : Turk J Vet Anim Sci 2010, 34 441 445 Turk J Vet Anim Sci, vol 34, iss 5