Antigenic Diversity of Bovine Viral Diarrhoea Viruses (BVDV) Isolated in Turkey

Authors : Kadir YEŞİLBAĞ, İbrahim BURGU

Pages : 571-576

View : 22 | Download : 8

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :Sixty BVDV field strains isolated from different regions of Turkey were antigenically characterised with a panel of 16 monoclonal antibodies insert ignore into journalissuearticles values(mAbs); specific to viral proteins E2 and NS2-3. MAb recognition patterns were detected by an indirect peroxidase-linked antibody assay and data were subjected to computer analysis for discussing herd specificity of viral strains isolated from immunotolerant, persistently infected insert ignore into journalissuearticles values(IPI); cattle. For that purpose, phylogenic and statistical analyses were performed. A high level of antigenic diversity was detected among the isolates. Diversity was also exhibited in IPI strains originating from the same herd. In some herds, viruses were divided into 2 viral subpopulations that were antigenically distinct from each other. The viruses in the subpopulations were significantly different from the viruses in the twin-subpopulation, as well as from viruses in other herds. This study demonstrated epitopic properties of Turkish BVDV field strains; yet, the results of this study do not support the concept of herd specificity of the virus.
Keywords : Bovine viral diarrhoea, BVDV, monoclonal antibodies, antigenic diversity, phylogenetic analysis, herd specificity