A Study on the Effects of Levamisole on the Immune System of Rainbow Trout (Oncorhynchus mykiss, Walbaum)

Authors : Ünal İSPİR, Mustafa DÖRÜCÜ

Pages : 1169-1176

View : 35 | Download : 7

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :The effects of levamisole on the specific and non-specific immune mechanisms of rainbow trout insert ignore into journalissuearticles values(Oncorhynchus mykiss, Walbaum); were examined. The weight of the 60 fish used insert ignore into journalissuearticles values(30 in the control group and 30 in the experimental group); in this study was 99.4-216.0 g. After injecting 5 mg kg-1 of levamisole intraperitonally, blood was taken from the heart of 30 anesthetized fish and hematocrit, leucocrit, leucocyte level, glass-adherent Nitroblue tetrazolium insert ignore into journalissuearticles values(NBT); positive cell activation, NBT activities, phagocytic activity, potential killing activities of neutrophyl and monocytes, myeloperoxidase production insert ignore into journalissuearticles values(MPO);, immunoglobulin, lysozyme and ceruloplasmin insert ignore into journalissuearticles values(Cp); activity were determined on days 3, 7, 10 and 14. The same procedure was conducted on a control group. No differences were found in the levels of hematocrit, leucocrit or immunuglobulin between the control and experimental groups insert ignore into journalissuearticles values(P > 0.05);. However, there were considerable increases in the other immune parameters and significant differences were detected between the control and experimental groups insert ignore into journalissuearticles values(P < 0.05, P < 0.01, P < 0.001);.
Keywords : Immunomodulation, immunity, levamisole, rainbow trout