The Effects of Fenfluramine on Blood and Tissue Serotonin (5-Hydroxytryptamine) Levels in Rats

Authors : İbrahim PİRİNÇCİ, Ahmet ATEŞŞAHİN, İzzet KARAHAN

Pages : 857-863

View : 22 | Download : 8

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :The aim of this study was to investigate the effect of fenfluramine insert ignore into journalissuearticles values(FEN); administered at single and repeated doses on brain, stomach and plasma serotonin insert ignore into journalissuearticles values(5-Hydroxytryptamine, 5-HT); levels in rats. FEN was injected intraperitoneally at single doses insert ignore into journalissuearticles values(1, 3 and 10 µmol kg-1); and given orally at repeated doses insert ignore into journalissuearticles values(1.25, 5 and 10 mg kg-1); for 21 days. The tissues and plasma samples were collected 20, 40, 80 and 160 minutes after the single dose administrations and 4 h after the last dose administration in repeated experiments. In addition, the rats treated with the dose of 1.25 mg kg-1 were maintained until 2 and 8 weeks and the tissues were taken at these times. The 5-HT levels in the tissue and plasma were measured by using high performance liquid chromatography insert ignore into journalissuearticles values(HPLC);. The levels of brain 5-HT were decreased at the single FEN doses when compared with the control group. At the repeated experiments, although no effect was observed at the dose of 1.25 mg kg-1; decreases were determined in brain 5-HT levels at the high doses. The levels of 5-HT in the stomach were found to increase in both single and repeated administrations. Decreases in levels of plasma 5-HT were determined in all experimental groups. In conclusion, while fenfluramine was determined to decrease brain and plasma 5-HT levels generally, it increased the levels of stomach 5-HT.
Keywords : Fenfluramine, rat, brain, stomach, plasma, serotonin