Effects of Hypertonic Sodium Chloride, Hypertonic Sodium Chloride + Sodium Bicarbonate and Hypertonic Sodium Chloride + Ringer`s Lactade Solution in the Treatment of Dogs with Experimentally Induced Endotoxaemia

Authors : Hasan BATMAZ, Zeki YILMAZ

Pages : 339-347

View : 14 | Download : 6

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :The aim of this study was to compare the effects of isotonic sodium chloride insert ignore into journalissuearticles values(ISS-0.9%);, hypertonic sodium chloride insert ignore into journalissuearticles values(HSS-7.2%);, HSS + lactate ringer solution insert ignore into journalissuearticles values(LRS); and HSS + sodium bicarbonate solution insert ignore into journalissuearticles values(SBS-1.3%); in the treatment of dogs with endotoxaemia. Endotoxaemia was induced by slow injection of a 1 mg/kg/i.v. dose of E. coli endotoxin insert ignore into journalissuearticles values(0111:B4);. At the treatment stage, four groups, each composed of six dogs, were formed and a different treatment plan was carried out in each group: ISS, HSS, HSS + LRS and HSS + SBS. Clinical, haematological and biochemical examinations were performed before and after endotoxaemia. Hypotension insert ignore into journalissuearticles values(MAP < 60 mm Hg);, leukopaenia and trombocytopaenia were observed during endotoxaemia in all dogs. MAP and plasma volume were increased in all groups except the ISS group. HCO-3 values were increased in the HSS + SBS group and decreased in the other groups. Therefore, it was concluded that the HSS + SBS combination was the most effective model of fluid therapy in the treatment of dogs with endotoxaemia.
Keywords : Sodium chloride, lactate ringer, sodium bicarbonate, endotoxaemia, dog