Pharmacokinetics of Oxytetracycline in Rainbow Trout (Oncorhynchus mykiss) Following Administration of Medicated Feed

Authors : İdris TÜREL, Gürdal DAĞOĞLU, Orhan YILMAZ

Pages : 223-227

View : 30 | Download : 10

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :The pharmacokinetics of oxytetracycline insert ignore into journalissuearticles values(OTC); were investigated in rainbow trout in freshwater at 10.5 oC. A group of 70 fish received OTC, an intravascular injection insert ignore into journalissuearticles values(i.v.); of 5 mg/kg body weight. Another group of 105 fish were fed medicated feed containing a dose of 100 mg/kg body weight. OTC plasma concentrations were determined by high performance liquid chromatography. The pharmacokinetic parameters were described by a two-compartment open model giving distribution half-lives of 0.907 h and 16.058 h, and elimination half-lives of 33.5 h and 27 h for i.v. and oral administration of OTC, respectively. After i.v. administration of OTC, other pharmacokinetic parameters estimated were the area under the curve insert ignore into journalissuearticles values(AUC: 145.078 ± 4.45 mg.ml-1.h-1); and mean residence time insert ignore into journalissuearticles values(MRT: 40.604 ± 1.150 h);. Following oral administration, AUC was 34.46 ± 1.189 mg.ml-1.h-1; MRT was 59.272 ± 1.541 h; Cmax was 0.577 mg/ml and Tmax was 36 h. The oral bioavailability insert ignore into journalissuearticles values(F); of OTC in rainbow trout was found to be only 1.187%.
Keywords : Rainbow trout, oxytetracycline, pharmacokinetic, oral bioavailability