Expression of Subunits of AMPA-Type (Ionotropic) Glutamate Receptors in the Rat Spinal Cord

Authors : Mümtaz NAZLI

Pages : 221-225

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Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :The distribution of ionotropic glutamate receptor subunits insert ignore into journalissuearticles values(GluR1-4);, considered a-amino-3-hydroxy-5-methyl-4-isaxole propionic acid type insert ignore into journalissuearticles values(AMPA-type);, was investigated in the rat spinal cord by immunocytochemistry. Different distributions of the AMPA-type glutamate receptor subunits were observed in the spinal cord. Immunolabelling with antibodies to both GluR1 and GluR2/3 revealed intensive staining in the dorsal horn, while staining for GluR2/3 and GluR4 revealed dense motor neurones in the ventral horn. These results suggest that in the rat spinal cord AMPA-type glutamate receptors vary in composition according to the region where they are expressed.
Keywords : AMPA type glutamate receptors, excitatory amino acids, spinal cord