Effects of 5-Fluorouracil and Mitomycine-C on Glaucoma Filtration Surgery in Rabbits

Authors : Servet KILIÇ

Pages : 309-315

View : 16 | Download : 8

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :The purpose of this study was to examine the effects of 5-fluorouracil insert ignore into journalissuearticles values(5-FU); and mytomycine-C insert ignore into journalissuearticles values(MMC); on the success rate of glaucoma filtration surgery insert ignore into journalissuearticles values(GFS);. A superior fornix-based conjunctival flap was created on the right eyes of 12 rabbits divided randomly into three equal groups termed groups 1, 2 and 3. After a small piece of sponge soaked with balanced salt solution insert ignore into journalissuearticles values(BSS); in group 1 insert ignore into journalissuearticles values(control);, 5-FU insert ignore into journalissuearticles values(50 mg/ ml); in group 2 and MMC insert ignore into journalissuearticles values(0.02 mg/ ml); in group 3 was kept on the filtration sites for 5 minutes, the filtration fistula insert ignore into journalissuearticles values(sclerectomy); was performed and the flap was replaced. Postoperatively, BSS, 5-FU and MMC with doses of 0.1 ml were injected 4 times with certain intervals into the inferior fornixes of the same groups. The presence of the corneal edema, neovascularization and defect, appearance of the filtering bleb, states of the aqueous humor, iris, lens and changes in intraocular pressure insert ignore into journalissuearticles values(IOP); were observed. In one case, severe conjunctival hyperemia associated with the corneal flush and hyphema was determined. A mild corneal edema in half the members of group 1, and all the members of groups 2 and 3, was found. The IOP, which reduced sharply in all cases immediately after the GFS, reached its preoperative level approximately in 14, 28 and 51 days in groups 1, 2 and 3, respectively. There was a significant difference insert ignore into journalissuearticles values(P
Keywords : Antiproliferatives, Glaucoma Filtration Surgery, Rabbit