Effects of Propylthiouracil-Induced Hypothyroidism on Plasma Lipid Table in Rabbits

Authors : İsmail ÇELİK, Vedat TÜRKOĞLU, Esref YEĞİN

Pages : 149-152

View : 16 | Download : 7

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :Hypothyroidism is commonly associated with hyperlipidemia. The aim of this study was to investigate the effect of Propylthiouracil-induced hypothyroidism on the plasma lipid profile in rabbits. This investigation was performed on male, white New Zealand insert ignore into journalissuearticles values( Oryctolagus cuniculus huxley); rabbits. Twenty rabbits were used; each of the two groups insert ignore into journalissuearticles values(hypothyroidism and control); consisted of ten animals. Hypothyroidism was induced by oral administration of Propylthiouracil 50 mg.kg -1 for three weeks. The mean values of Triiodothyronine insert ignore into journalissuearticles values(T 3 );, thyroxine insert ignore into journalissuearticles values(T 4 );, free T 3 insert ignore into journalissuearticles values(FT 3 ); and free T 4 insert ignore into journalissuearticles values(FT 4 ); were 121.7±32.7 ng/d1, 1.81±0.60 µg/dl, 2.36±9b92 ng/dl and 0.43±0.22 p mol/dl in the control group, and 88.4±19.2 ng/dl, 1.15±0.37 µg/dl, 1.48±0.44 ng/dl and 0.18±0.11p mol/dl in the hypothyroidism group, respectively insert ignore into journalissuearticles values(p
Keywords : Hypothyroidism, lipid, rabbit