Comparasion of Pharmacokinetic Profiles of Some Antimicrobial Agents in Plasma and Lymph Fluids

Authors : Muammer ELMAS, Bünyamin TRAS

Pages : 591-598

View : 20 | Download : 11

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :Some pharmacokinetic parameters and concentrations of four antimicrobial agents in plasma and lymph fluids were compared for determination of penetration into peripheral tissues. Eighteen healthy, adult sheep insert ignore into journalissuearticles values(Turk Merino x Hampshire cross, 18-24 month, weighing 32-37 kg); were used. For collection of lymph samples, the efferent vessel of NI. cervicalis superficialis sinister was cannulated with a polyethylene catheter. All antimicrobial agents were administered intramuscularly at single recommended doses insert ignore into journalissuearticles values(Chloramphenicol 30 mg/kg b.wt., Enrofloxacin 2.5 mg/kg b. wt., Sulphadoxine-trimethoprim 16 mg/kg b.wt.);. Subsequently, blood and lymph samples were concurrently obtained at 2, 4, 8, 12, 16 and 24 hr postinjection. Concentrations of these agents in all samples were analysed by HPLC. Concentrations of enrofloxacin in lymph fluids at all sampling times were found to be higher than plasma insert ignore into journalissuearticles values(p0.05);. The level of chloramphenicol in plasma was found to be higher than lymph fluid only at 2 hr insert ignore into journalissuearticles values(p
Keywords : Chloramphenicol, enrofloxacin, sulfadoxin, trimethoprim, lymph fluids, pharmacokinetic profiles