Comparison of the Distribution of C-fos With Primary Afferent Markers

Authors : Zafer SOYGÜDER

Pages : 499-504

View : 16 | Download : 7

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :The neuropeptides Substance P insert ignore into journalissuearticles values(SP); and Calcitonin gene related peptide insert ignore into journalissuearticles values(CGRP); were used as markers for peptidergic primary afferent fibres. A lectine, Griffonia simplicifolia insert ignore into journalissuearticles values(Bandeiraea simplicifolia);Isolectin-B4 insert ignore into journalissuearticles values(GSA I-B4);, was used as a marker for non-peptidergic primary afferent fibres. C-Fos immunoreactivity was determined in the spinal cord of rats which had received 100% mustard oil application in the right hind limb. Darkly labelled c-Fos immunoreactive cells were concentrated in laminae I-IIo of the dorsal horn. SP and GSA I-B4 were distributed almost in the same regions. CGRP was more abundant in laminae I-IIo with someimmunoreactive fibres in lamina IIi. These data suggest that a population of peptidergic and non-peptide primary afferents may play an important function in the induction of c-fos by mustard oil.
Keywords : c fos, neuropeptides, lectin, primary afferent fibres, spinal cord