Maternal embryokines that regulate development of the bovine preimplantation embryo

Authors : Peter James HANSEN, Anna Carolina DENICOL, Kyle Bradley DOBBS

Pages : 589-598

Doi:10.3906/vet-1405-96

View : 18 | Download : 8

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :Proper embryonic development depends upon regulatory signals from the reproductive tract called embryokines. This review uses the cow as a model to understand the developmental processes controlled by embryokines. The focus is on 3 embryokines that have been shown to increase competence of embryos to survive after transfer to recipients: CSF2, IGF1, and DKK1. Together, these molecules regulate key events required for development of the embryo to the blastocyst stage including proliferation insert ignore into journalissuearticles values(enhanced by IGF1);, development of the inner cell mass insert ignore into journalissuearticles values(regulated by CSF2);, control of differentiation insert ignore into journalissuearticles values(modified by DKK1);, and inhibition of apoptosis and stress-mediated developmental arrest insert ignore into journalissuearticles values(IGF1 and CSF2);.
Keywords : Embryo, embryokine, colony stimulating factor 2, insulin like growth factor 1, dickkopf 1