Screening for S32G mutation of BMP15 gene in 18 goat breeds

Authors : Tao FENG, MingXing CHU, GuiLing CAO, DongWei HUANG, Ran DI

Pages : 463-468

Doi:10.3906/vet-1401-97

View : 18 | Download : 8

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :In our early work, one mutation insert ignore into journalissuearticles values(A898G, which caused Ser32Gly insert ignore into journalissuearticles values(S32G); change of mature peptide); was identified in the goat BMP15 gene and the allele G was associated with high litter size in Jining Grey goats insert ignore into journalissuearticles values(the goat breed with the highest fecundity in China);. The aim of this research was to investigate the genetic structure of the prolific BMP15 gene in 18 goat breeds reared in China, including 12 native breeds, 3 introduced breeds, and 2 cultivated breeds. Genomic DNA of 1011 goats was screened for the S32G mutation. The results showed that this mutation existed in all 3 cultivated and 8 native goat breeds but in none of the 3 introduced goat breeds, which hinted that this mutation may originate from native goat breeds of China. Besides the Jining Grey goats, the BMP15 gene was also a potential prolificacy gene in Matou goats. Moreover, the structure prediction indicated that the S32G mutation might participate in the binding of BMP15 with receptors.
Keywords : Goat, prolificacy, bone morphogenetic protein 15 gene, functional analysis