Influences of flunixin and tenoxicam on the pharmacokinetics of florfenicol in lipopolysaccharide-induced endotoxemia

Authors : Feride KOÇ, Alptuğ ATİLA, Emre KARAKUŞ, Kamil ÜNEY

Pages : 168-173

Doi:10.3906/vet-1411-57

View : 31 | Download : 10

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :The purpose of this study was to investigate the influences of flunixin insert ignore into journalissuearticles values(FM); and tenoxicam insert ignore into journalissuearticles values(TN); on the pharmacokinetics of florfenicol insert ignore into journalissuearticles values(FF); after coadministration in lipopolysaccharide insert ignore into journalissuearticles values(LPS);-induced endotoxemic rabbits. Fifteen male rabbits were used in this study. FF insert ignore into journalissuearticles values(20 mg/kg);, FM insert ignore into journalissuearticles values(2 mg/kg);, and TN insert ignore into journalissuearticles values(1 mg/kg); were coadministered via intravenous injection to the animals. The concentrations of FF were determined by high-performance liquid chromatography with diode-array detection from 0.08 to 12 h in plasma. The plasma concentration-time profile of FF was described using a noncompartmental open model. In this study, terminal half-life, area under the curve, mean residence time, and volume of distribution at steady state were significantly increased, whereas total body clearance was decreased in coadministered groups. In conclusion, FM and TN have effects on the pharmacokinetics of FF in coadministered endotoxemic rabbits. When FF is coadministered with FM and TN, it can be given at a dose of 20 mg/kg b.w. every 8 h for treatment of infections caused by susceptible pathogens with a minimum inhibitory concentration insert ignore into journalissuearticles values(MIC); of = Keywords: Pharmacokinetics, florfenicol, rabbit, flunixin, tenoxicam, lipopolysaccharide Full Text: PDF
Keywords : Pharmacokinetics, florfenicol, rabbit, flunixin, tenoxicam, lipopolysaccharide