Serum pharmacokinetics and tissue concentrations of a newrecrystallized enrofloxacin hydrochloride-dihydrate in hamsters

Authors : Alma CARRASCOSA, Alejandro De La PEÃ`A, Lilia GUTIERREZ, Hector SUMANO

Pages : 661-667

View : 17 | Download : 10

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :Pharmacokinetics insert ignore into journalissuearticles values(PK);, pharmacodynamics insert ignore into journalissuearticles values(PD);, and PK/PD ratios of a new solvate of enrofloxacin insert ignore into journalissuearticles values(enrofloxacin hydrochloride-dihydrate; enro-C);, were studied in hamsters. Enrofloxacin from Baytril1397904493 5% insert ignore into journalissuearticles values(enroR); served as the reference preparation. Two groups of 60 Syrian golden hamsters were intramuscularly injected individually with 10 mg/kg of enroR or with enro-C. Tissue and serum samples were obtained for 72 h; enrofloxacin concentrations were determined by HPLC with UV detection. Ninety percent minimum inhibitory concentrations insert ignore into journalissuearticles values(MIC90); were determined for strains of methicillin-resistant Staphylococcus aureus, Leptospira interrogans, and Escherichia coli. All PK variables were statistically different between groups insert ignore into journalissuearticles values(P < 0.01);. CMAX of enrofloxacin for enro-C was 17.3 μg/mL and it was 2.6 μg/mL for enroR. AUC was considerably higher for enro-C insert ignore into journalissuearticles values(459.2 μg/mL h vs. 19.9 μg/mL h);. There were no statistically significant differences in MIC90 values between enroR and enro-C. Tissue concentrations of enro-C in all cases were higher and remained above the MIC for longer periods than those of enroR. Relevant PK/PD ratios for enrofloxacin insert ignore into journalissuearticles values(AUC/MIC ? 125 and CMAX > MIC = 10-12); are consequently superior for enro-C. Given the outstanding PK/PD ratios of enro-C, this new moiety is proposed as a possible solution when high tissue concentrations of enrofloxacin are necessary.
Keywords : Enrofloxacin, enro C, hamster, pharmacokinetics pharmacodynamics, tissue concentrations, Staphylococcus aureus, Leptospira interrogans, Escherichia coli