Effects of Epimedium polysaccharide on female mouse (Mus musculus)ovarian and uterine development

Authors : SETH YAW AFEDO, YAPING XU, CAROLINE WANJIKU MUNERI, GUOCHAO NI, WEICHAO XU, RONG RUI

Pages : 714-718

View : 16 | Download : 8

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :This study was conducted to investigate the effects of Epimedium polysaccharide insert ignore into journalissuearticles values(EPS); on ovarian and uterine development in female mice and assess the in vitro maturation insert ignore into journalissuearticles values(IVM); rate. Healthy Kunming female mice were divided into 4 groups and administered 2, 4, 6, and 8 mg/0.1 mL of EPS, respectively; the control group was given 0.1 mL of 0.9% physiological saline solution. After 7 and 14 days, the mice were sacrificed and their reproductive tracts insert ignore into journalissuearticles values(uterus, oviduct, and ovaries); were removed. The reproductive tract was weighed; some ovaries were punctured to harvest oocytes for IVM culture and the others were used for histological analysis. EPS had virtually no effect on the body weight of the female mice. EPS at 4 mg/0.1 mL for 14 days of treatment had a significant effect insert ignore into journalissuearticles values(P < 0.05); on ovarian and uterine development when compared with 2, 6, and 8 mg/mL but no significant effect insert ignore into journalissuearticles values(P > 0.05); when compared with the control group. The number of follicles increased in the experimental groups and the arrangements of ovarian follicles were not negatively affected during histological observation. In conclusion, EPS at appreciable dosages has a positive effect on mouse ovarian development.
Keywords : Epimedium polysaccharide, ovaries, development, in vitro maturation, reproductive index